Anti-TNF therapy alone was noninferior to a combination of surgery and anti-TNF therapy in fistula healing in patients with perianal fistulizing Crohn's, a meta-analysis showed.
Antitumor necrosis factor therapy alone yields outcomes comparable with those seen with anti-TNF therapy combined with surgery in patients with perianal fistulizingResearchers conducted a systematic review and meta-analysis of 13 studies that included 1251 patients who received combination therapy of surgical intervention and anti-TNF therapy , surgical intervention alone , or anti-TNF therapy alone .Co-primary outcomes were fistula response and fistula healing .
=.28) were not different among patients treated with combination therapy and those treated with anti-TNF therapy alone.=.05) than those treated with surgical intervention alone; however, only three studies made this comparison."Perianal fistula response and healing in PFCD occurred more frequently in patients treated with combined surgical intervention and anti-TNF therapy compared with surgical intervention alone but not with anti-TNF therapy alone," the authors wrote.
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