Peanut allergy treatment may increase risk of anaphylaxis, study finds.
appears to work when tested in the doctor’s office, it may significantly increase allergic and anaphylactic reactions outside the clinic, a new study finds.
After pooling the results of 12 clinical trials that included a total of more than 1,000 patients, researchers found that compared with avoiding peanut exposure and placebo treatments, oral immunotherapies were associated with three times the risk of anaphylaxis and nearly twice the number of serious adverse events, according to the study published in The Lancet.
“The premise of the studies was based on the assumption that if you can eat peanut in the clinic you will be desensitized and that will translate into desensitization everywhere else,” said the study’s lead author, Dr. Derek Chu, a fellow in clinical immunology and allergy at McMaster University in Hamilton, Ontario. “But assumptions don’t always turn out to be true.”Part of the problem is that testing in a medical clinic is a controlled environment.
The researchers analyzed 12 studies on peanut oral immunotherapy, involving 1,041 patients whose average age was 8.7 years. Three of the trials included in the new study had not been published. When the patients from all 12 trials were pooled in a single analysis, some disturbing trends popped out.The risk of anaphylaxis among children receiving oral immunotherapy turned out to be more than three times higher than in kids avoiding the allergen or treated with placebo medication.
Oral immunotherapy was also associated with a higher risk of serious adverse events and allergic reactions such as vomiting, upper respiratory tract reactions, and swelling.
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