Researchers have created a computer program that can unravel the mysteries of how proteins work together -- giving scientists valuable insights to better prevent, diagnose and treat cancer and other diseases. The tool uses artificial intelligence (AI) to build the three-dimensional atomic structure of large protein complexes.
Researchers have created a computer program that can unravel the mysteries of how proteins work together -- giving scientists valuable insights to better prevent, diagnose and treat cancer and other diseases. The tool uses artificial intelligence to build the three-dimensional atomic structure of large protein complexes.
"Cryo-EM right now is a revolutionary, key technology for determining large protein structures and assemblies in cells," said Cheng, a Curators' Distinguished Professor of Electrical Engineering and Computer Science."But building protein structures from Cryo-EM data is labor intensive and requires a lot of human intervention, making it time-consuming and hard to reproduce. Our technique is fully automated and generates more accurate structures than existing methods.
The system analyzes cryo-EM images and identifies the individual atoms and their positions within a protein complex, even when there's no prior knowledge of the structure. The system can then assemble these atoms into a complete 3D model of protein complexes, providing insights into how proteins function.
"For instance, I have a drug, and I want to make it work better for some patients," Cheng said."Now I can use AI to change it and optimize it."
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