A new international study, including almost 75,000 participants worldwide, identifies 254 genetic variations influencing brain volume and the likelihood of ADHD and Parkinson’s disease.
Brain volume, and the genetic variants that influence it, is tied to ADHD and Parkinson’s disease risks, suggests one of the most extensive international studies to date on DNA and brain structure., examined how brain size and genetic differences influence key subcortical or ‘deep brain’ regions crucial for memory, emotional regulation, proprioception, sensory processing, and responses to rewards and punishments.
A team of 189 researchers from 45 countries analyzed data from genome-wide association studies and magnetic resonance imaging brain scans of 74,898 participants across 19 countries.
However, more studies are needed on the causal relationship between genes and brain-based diseases. “It’s worth noting that these are correlations, not causal relationships, and so interpretation must be approached with caution,” Rentería said.. “We plan to further investigate to identify the exact biological pathways involved.
Curtin, K., Fleckenstein, A.E., Keeshin, B.R., et al. . Increased Risk of Diseases of the Basal Ganglia and Cerebellum in Patients with a History of Attention-Deficit/Hyperactivity Disorder.Study Identifies Significant Genetic Overlap Between ADHD, Dyslexia
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