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, a pediatric neurologist who studies the medication, called leucovorin, told The Post. “We can’t schedule anymore patients until 2028.” Now, with the drug out of reach, some parents are turning to over-the-counter folic acid supplements, which they hope can serve as a substitute — but the move, Frye warned, “may do more harm than good.
”is a prescription drug that has traditionally been used to protect healthy cells during chemotherapy. It’s a form of folate, or vitamin B9, an essential nutrient our bodies need but cannot produce on their own.that some children with neurodevelopmental disorders, including autism, have low levels in their brains — a condition called cerebral folate deficiency.found that more than 75% of children with autism carry these antibodies, compared with just 10-15% of kids without the disorder.Common appliance in a third of US homes is increasing your risk of lung cancer and diabetes The real horrors of the 'scromiting' weed disorder plaguing ERs — from dramatic weight loss to 'nonstop puking' Intrigued, Frye began exploring whether leucovorin could bypass this blockage and deliver folate directly to the brain, potentially easing symptoms in some children with autism.Fast forward to September, when federal health officials announced they would update leucovorin’s label to allow its use for children with “cerebral folate deficiency and autistic symptoms,” citing studies like Frye’s.My nonverbal autistic son began speaking at age 8 after taking wonder drug — he’d understood everything for years and had complaintsas a treatment for autism, saying in a statement that “more studies are necessary before a conclusion can be reached.”But the barriers to access are high. Some, desperate, have turned to folic acid, a form of vitamin B9 sold over the counter. But Frye warned this is not a substitute.“People don’t understand that vitamins are very complex chemicals and treatment with them is not that simple,” Frye said. “What you’re giving, it’s just like a drug.” Though both leucovorin and folic acid are forms of B9, there’s a crucial difference. Leucovorin is an active form that the body can use immediately, while folic acid is synthetic and must be converted first. “Our bodies can only activate about 400 micrograms a day, which is what is in your standard or a little even high dose multivitamin, so that’s OK,” Frye explained.Leucovorin doses, by contrast, are in milligrams — far higher than standard folic acid supplements. “I have had parents who’ve gone to neurologists and had the neurologist tell them that is just like folic acid, so just take a lot of it,” Frye said. “You can’t do that.”Too much folic acid can overwhelm the body’s conversion process, leaving unmetabolized folic acid in the blood. In pregnant women, Frye said, studies suggest this could increase the risk of autism in their children. For kids with cerebral folate deficiency and autism, he explained, “we think that the folic acid will essentially plug the transporter,” making it even harder for the nutrient to reach the brain. “We actually recommend no folic acid for them,” Frye added, Frye added, noting that while the data isn’t definitive, it could potentially worsen their autism symptoms, including behavioral challenges. “Folic acid is good to a point, like in your everyday regular supplement. But if you need higher doses of folate because of a folate deficiency or other metabolic issues, you can’t use folic acid,” Frye stressed. “Actually, you may do more harm than good.”Red Apple deal: Flex your wrist and wallet with $150 off an Apple Watch in this rare shadeMichigan football coach jailed on suspicion of assault after shocking firing over 'inappropriate relationship'Inside Michigan coach's 'strange' behavior before his firing for 'inappropriate' relationship with staffer, shocking arrestRestaurant owned by famed NYC news anchor robbed of $2.5M by brazen staffer who used siphoned cash to buy houseáòõÃâûðýð ÃÅøÃâ°ÃµÃ½ÃºÃ¾ - stock.adobe.com
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