Advancements in understanding the disease could bring about a paradigm shift. For a long time, osteoarthritis was believed to stem from wear and tear in our later years. However, recent research increasingly connects the breakdown of cartilage to inflammatory and metabolic activities within the joi
Researchers have discovered that elevated levels of the protein c-Fos are associated with osteoarthritis severity, providing new insights into potential targeted therapies. Osteoarthritis, a debilitating joint disease affecting over 500 million globally, may be significantly influenced by this protein.For a long time, osteoarthritis was believed to stem from wear and tear in our later years.
As the current research also showed, cartilage samples from humans and mice with osteoarthritis have elevated levels of c-Fos. The protein is secreted by cartilage cells in response to OA signals and plays a role in protecting cartilage. Subsequently, the scientists deciphered the mechanism in the metabolism of cartilage cells that controls the production and accumulation of c-Fos. “Our findings are an important step towards the development of targeted therapies in the form of drugs based on the newly discovered control mechanism of c-Fos expression in cartilage cells,” says study leader Erwin Wagner, highlighting the high relevance of the research work.
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