A new study suggests that promoting specific bacteria in the mouth may help delay cognitive decline.
A new study from the University of Exeter in the UK suggests that promoting specific bacteria in the mouth could potentially delay cognitive decline . Researchers found that individuals with mild cognitive impairment (MCI) who hosted a relatively high abundance of bacteria from the genus Neisseria-Haemophilus tended to have better cognitive function.
The study, led by molecular biologist Joanna L'Heureux and her colleagues, focused on the link between oral microbiome composition and cognitive health. They discovered that of 33 participants with MCI who were genetically predisposed to Alzheimer's disease, many had oral microbiomes dominated by the Neisseria-Haemophilus genus. Interestingly, this dominance was a predictor for an elevated genetic risk for dementia, suggesting it could be used as an early marker of disease risk.Scientists suspect that certain bacteria in the mouth, like those in the Neisseria-Haemophilus genus, may produce nitric oxide. This signaling molecule is thought to play a protective role in the central nervous system by boosting neural plasticity and improving the efficiency and power of neural messages. Nitric oxide may also reduce neural inflammation. The authors of the study believe that by influencing the composition of the oral microbiome, it might be possible to influence nitric oxide availability and, consequently, brain health. However, further research is needed to fully understand the complex interplay between oral bacteria, the production of signaling molecules, and cognitive function
Oral Microbiome Cognitive Decline Dementia Alzheimer's Disease Nitric Oxide
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