A new dose-finding study supported the potential of the carbonic anhydrase inhibitor as an alternative to CPAP machines.
An epilepsy drug sold in Europe as Ospolot and also known as sulthiame showed promise in reducing sleep disorder ed breathing and other symptoms of obstructive sleep apnea , based on data from nearly 300 individuals presented in a late-breaking study at the European Respiratory Society Congress 2024.
In the current study, the researchers sought to determine the most effective dose of sulthiame for patients with OSA. They randomized 298 adults with OSA who could not accept or tolerate oral splints or CPAP to 100 mg, 200 mg, or 300 mg of sulthiame daily or placebo . Peak efficacy occurred in the range of 200-300 mg and was similar for patients with moderate or severe OSA, Hedner said in his presentation.
Treatment-emergent adverse events were in line with the known safety profile of sulthiame and included paresthesia, headache, fatigue, and nausea; these were mainly moderate and dose-dependent, with no evidence of cardiovascular safety issues, he said. However, the results support sulthiame as an effective, well tolerated, and promising novel candidate for drug therapy in patients with OSA, worthy of phase 3 studies, Hedner said.The gold standard of treatment for OSA is a CPAP machine, but the effectiveness is limited by patient tolerance, said Q. Afifa Shamim-Uzzaman, MD, an associate professor and a sleep medicine specialist at the University of Michigan, Ann Arbor, Michigan, in an interview.
Sleep Apnoea Sleep Disturbance Abnormal Sleep Pattern Sleep Disorder Somnipathy Sleep Breathing-Related Sleep Disorder Central Sleep Apnea Central Sleep Apnoea Obstructive Sleep Apnea Obstructive Sleep Apnea Syndrome Obstructive Sleep Apnoea Obstructive Sleep Apnoea Syndrome Continuous Positive Airway Pressure CPAP Epilepsy Seizure Disorder Adherence
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