Newly discovered brain mechanism linked to anxiety, OCD MolPsychiatry
GFAP-Cre
males were bred to homozygous floxed females. Note that YFP, which is also under Cre control in the Ai32 allele, is only expressed in astrocytes , thus germline recombination is not being observed in these crosses. 3–4 month-old mice were used for implantation. All test mice were conditioned for 5–15 min in specific experimental rooms prior to the experiments. All behavioral experiments were conducted during day light period of the light/dark cycle.
A uniform genetic background is critical for obtaining reproducible mouse behavioral studies. For this reason, every mouse strain that we have used for these experiments was extensively backcrossed , allowing us to use C57Bl/6 mice as controls, among others.All survival surgeries were performed under aseptic conditions under stereotaxic equipment . Mice were anaesthetized using 4.0% isoflurane during induction and maintained at 1.5% throughout the surgical procedure.
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