It's not too late—join ScienceWebinars tomorrow at 12 p.m. ET for: Exploring single-cell multiomics in development and aging. Learn more and register today: webinar
Epigenetic information is relatively stable in somatic cells but is reprogrammed on a genome-wide scale in germ cells and early embryos. Reprogramming is essential for imprinting, for the return to naïve pluripotency, for the erasure of epimutations, and for the control of transposons. Following reprogramming, epigenetic marking occurs prior to and during lineage commitment in the embryo.
This webinar will address the mechanisms and consequences of global epigenetic reprogramming in the germ line and at zygotic genome activation. Using single-cell multiomics techniques, researchers are beginning to chart epigenetic and transcriptional dynamics and heterogeneity during the exit from pluripotency and initial cell-fate decisions leading up to gastrulation.