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The most widely used application of CRISPR-Cas9 is to target a gene of interest and generate a double-strand break at the target site. But what if you could use the highly specific CRISPR-Cas9 system to target your gene of interest and alter its expression without cutting the DNA backbone? Making use of a deactivated or dead Cas protein bound to activator or repressor domains achieves just that.
While similarities do exist between CRISPRi and CRISPR knockout for loss-of-function experiments, CRISPRi allows for multiplexed repression experiments without concern for DSBs triggering cell death via the DNA damage response pathway.
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