Ohio State Opens As a 28-Point Favorite Over Indiana in Season Opener

Ohio State opens as a four-touchdown favorite for its season opener at Indiana this fall.

The Buckeyes have beaten the Hoosiers by at least 20 points in six of their last seven matches, including a dominant 56-14 win in Columbus last season and a 54-7 thrashing the last time OSU traveled west to Bloomington in 2021. Ohio State has defeated Indiana in 27 straight matchups, with its last loss to the Hoosiers taking place all the way back in 1988, when the Buckeyes lost back-to-back games to the Hoosiers.

The last time a first-year starting quarterback began the season under center was in 2021, when C.J. Stroud led the Buckeyes to a 45-31 win at Minnesota while completing 13-of-22 passes for 294 yards, four touchdowns and one interception.

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