News & Views: Jennifer Brudno & James Kochenderfer theNCI discuss off-the-shelf CARTcells. A phase 1 trial in melanoma shows feasibility and preliminary efficacy, but how might these fit into the treatment landscape?
Nevertheless, generation of autologous CAR T cell products is extremely time consuming and costly, prompting researchers to explore alternative strategies to overcome these limitations.
In this issue ofreport results of part A of the phase 1 UNIVERSAL clinical trial, which evaluated ALLO-715, an allogeneic off-the-shelf anti-BCMA CAR T cell product. The study demonstrated that administering these off-the-shelf CAR T cells is feasible, and that the therapy has clear anti-malignancy activity in multiple myeloma.
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