Obesity May Permanently Change the Brain – Yale Study Finds Severely Impaired Response to Nutrients — A new research study revea |
Researchers from Yale found that obesity is associated with diminished brain response to nutrient intake, which doesn’t recover even after weight loss. The study offers insights into why maintaining weight loss is challenging for some people and emphasizes the significant role of the human brain in obesity.
These differences in brain activity, the researchers say, could help explain why it’s difficult for some to lose weight and maintain weight loss.Over 4 million people die each year around the world as a result of being overweight, according to the World Health Organization, and understanding the biological factors that contribute to obesity will be essential for addressing its devastating, global impact, say researchers.
“This was surprising,” said Serlie, a professor of medicine at Yale School of Medicine and senior author of the study. “We thought there would be different responses between lean people and people with obesity, but we didn’t expect this lack of changes in brain activity in people with obesity.” These findings, the researchers said, are compatible with reduced nutrient sensing in people with obesity.
Prior analyses have found that most people who lose weight regain it within a few years of dieting. These new findings, the researchers say, may help explain why that’s so often the case.
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