A topical therapy that combines three acne medications applied once a day showed efficacy superior to a vehicle in two phase 3 studies of children and adults with moderate to severe acne.
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit.The two multicenter studies included 363 individuals aged 9 years and older with moderate to severe acne from 30 centers, including 15 in North America.
Moderate to severe acne was defined as having 30 to 100 inflammatory lesions , 35 to 150 noninflammatory lesions , and at least two nodules.Treatment success was defined as a reduction of at least two grades from baseline on the Evaluator's Global Severity Score and lesion counts of clear or almost clear at weeks 2, 4, 8, and 12.Treatment success occurred in 49.6% of the IDP-126 group, vs 24.9% of the vehicle group in study 1, and in 50.5% of the IDP-126 group, vs 20.
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