Novel technology enables better understanding of complex biological samples

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Novel technology enables better understanding of complex biological samples
BiotechnologyBiologyBiotechnology And Bioengineering
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Researchers have developed a novel technology that allows the distribution of components within a single cell to be accurately detected and visualized.

Positioning a t-SPESI unit above an inverted fluorescence microscope allows visualization of both the sample and the exact location of chemical components analyzed. This provides an increased understanding of complex biological samples, aiding the development of advanced therapies and diagnostic techniques.

t-SPESI is a technique that allows analysis of the spatial layout of molecules in a sample. Multiple micro-samples of different regions of a cell are taken and transferred for analysis by a technique called mass spectrometry, which can determine the exact chemical components in that region."We have developed a new t-SPESI unit that allows us to visualize the microscopy sample in multiple modes," explains lead author Yoichi Otsuka.

This technology can visualize the distribution of intracellular lipids, fatty compounds that play key roles in metabolic processes. Abnormal distributions and functions of lipids are known to be linked to disease.

Yoichi Otsuka, Kazuya Kabayama, Ayane Miura, Masatomo Takahashi, Kosuke Hata, Yoshihiro Izumi, Takeshi Bamba, Koichi Fukase, Michisato Toyoda.Using a new fluorescent mouse model with advanced imaging techniques, researchers have successfully visualized how musculoskeletal components are integrated into the functional locomotor system ...

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