Ivarmacitinib, a novel Janus kinase 1 inhibitor, may be considered a potential treatment for patients with moderate to severe active rheumatoid arthritis who have an inadequate response to csDMARDs.
Ivarmacitinib, a novel Janus kinase 1 inhibitor, alleviates symptoms, reduces disease activity, and improves physical function and quality of life in patients with moderate to severe
The patients were randomly assigned to receive either placebo or 4 mg ivarmacitinib or 8 mg ivarmacitinib once daily for 24 weeks, alongside background csDMARDs. Secondary endpoints included the proportion of patients achieving American College of Rheumatology 50/70 responses and, Disease Activity Score 28-joint count C-reactive protein ) score < 2.6 or ≤ 3.2, as well as measures of other patient-reported outcomes such as pain, physical function, and quality of life at 24 and 52 weeks.
Rheumatoid Arthritis (RA) Arthritis Joint Inflammation Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL Pain Pain Management Artificial Intelligence Deep Learning AI NPL Machine Learning ML Natural Language Processing Artificial Neural Networks C-Reactive Protein C-Reactive Protein (CRP) Hospitals Immunology
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