Mutations in our genetic makeup can result in severe problems, such as colon or liver cancer. However, cancer is an intricate disease and the same genetic mutations can result in varying subtypes of tumors in different individuals. Currently, there is no effective method for creating these tumor sub
has developed a novel technique for modeling certain subtypes of liver cancer tumors using the CRISPR-Cas9 gene-editing tool.
CSHL scientists created two liver tumor subtypes, imaged above, in mice. The left image shows a liver tumor subtype that is associated with the most common form of human liver cancer, hepatocellular carcinoma. On the right is a tumor subtype associated with a rarer liver cancer, mostly found in children, named hepatoblastoma. Credit: Beyaz lab/Cold Spring Harbor Laboratory
Beyaz and his colleagues produced two distinct tumor subtypes by targeting a single section of the mouse gene,, with CRISPR. The tool is mostly used to inhibit gene function. This is the first time CRISPR has been used to generate different cancer-causing gain-of-function mutations in mice. These mutations enhance protein activity to promote tumor growth. The team sequenced each tumor subtype to figure out which isoform was associated with the differences they observed.
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