A new Rutgers Health study reveals that a combination of acetaminophen and ibuprofen is more effective than opioids for managing pain after wisdom tooth extraction.
A Rutgers Health study found that a combination of acetaminophen (Tylenol) and ibuprofen (Advil, Motrin) controls pain after wisdom tooth removal better than opioids. The trial, involving more than 1,800 patients, showed that those given the combination of ibuprofen and acetaminophen experienced less pain, better sleep and higher satisfaction compared with those receiving the opioid hydrocodone with acetaminophen.
'We think this is a landmark study,' said Cecile Feldman, dean of Rutgers School of Dental Medicine and lead author of the study.'The results actually came in even stronger than we thought they would.' Dentists, who rank among the nation's leading prescribers of opioids, wrote more than 8.9 million opioid prescriptions in 2022. For many young adults, dental procedures such as wisdom tooth extraction are their first exposure to opioid medications. 'There are studies out there to show that when young people get introduced to opioids, there's an increased likelihood that they're going to eventually use them again, and then it can lead to addiction,' said study co-investigator Janine Fredericks-Younger, adding that opioid overdoses kill more than 80,000 Americans each year. To compare opioid and non-opioid pain relief, the researchers conducted a randomized trial on patients undergoing surgical removal of impacted wisdom teeth, a common procedure that typically causes moderate to severe pain. Half the patients received hydrocodone with acetaminophen. The other half got a combination of acetaminophen and ibuprofen. Patients rated their pain levels and other outcomes, such as sleep quality, over the week following surgery.showed the non-opioid combination provided superior pain relief during the peak-pain period in the two days after surgery. Patients taking the non-opioid medications also reported better sleep quality on the first night and less interference with daily activities throughout recover
OPIOID PAIN RELIEF WISDOM TEETH ACEAMINOPHEN IBUPROFEN
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