Although would-be COVID-19 therapies like the malaria drug hydroxychloroquine and the failed Ebola drug remdesivir have drummed up excitement as potentially life-saving treatments, a comprehensive review of available data finds that it's still too early to tell. The review, published in JAMA on
Although would-be COVID-19 therapies like the malaria drug hydroxychloroquine and the failed Ebola drug remdesivir have drummed up excitement as potentially life-saving treatments, a comprehensive review of available data finds that it's still too early to tell.
MORE: Questions remain over whether COVID-19 recovery will guarantee immunity: Is reinfection still possible? The JAMA review serves as a stark reminder that despite the hype, there have been no large randomized controlled trials, which are considered the gold standard of medical research. However, the JAMA review found no high-quality evidence demonstrating efficacy of hydroxychloroquine or its chemical cousin, chloroquine, to treat COVID-19. Although one small study in France revealed promising results that chloroquine may help -- touted by Trump -- the authors of the JAMA paper contend that the study suffered from serious design flaws."The number of problems in that paper is just staggering," said Dr.
The JAMA study recommends that patients with COVID should not receive steroids. Additionally, authors echo guidelines that patients should continue their ACE-inhibitors, a type of blood pressure medication. Finally, there is promising test tube data to suggest that the antiviral drug remdesivir might successfully treat COVID-19, although studies in people are still too limited to draw any conclusions.
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