The trial proved that nipocalimab reduced IgG antibodies, including anti-citrullinated protein autoantibodies, but the primary endpoint was missed.
did not meet its primary endpoint, but there could still be people with moderate to severe RA who might benefit from treatment with the drug, according to information reported at thewas the least squares mean change in Disease Activity Score in 28 joints using C-reactive protein from baseline to 12 weeks of treatment. This was reduced by −1.03 with nipocalimab and by −0.58 with placebo, giving a mean difference of just −0.45 .
Nipocalimab is a fully human, immunoglobulin G1 monoclonal antibody that is designed to selectively block the FcRn. By doing so, it essentially stops IgG from being recycled within the immune system, and this in turn lowers IgG levels. That includes potentially harmful ACPAs, among other pathogenic antibodies, Taylor and fellow investigators explained in
Taylor responded that total IgG had been reduced by about 65% and ACPA by about 40%. Why this difference exists is not yet clear. It could be because ACPA are part of complexed antibodies.–positive," said Taylor, pointing out that although IgM"wouldn't normally be affected by FcRn blockade," there was a 10% reduction in RF IgM, probably because it was complexed to IgG.
RA - Rheumatoid Arthritis Rheumatoid Arthritis (RA) Igg Immunoglobulin G Anti-Tnf Anti-Tumor Necrosis Factor Anti-Tumour Necrosis Factor Arthritis Joint Inflammation Iga Immunoglobulin A Monoclonal Antibody Cetuximab Rituximab Biologic Therapy Biologics Systemic Lupus Erythematosus SLE - Systemic Lupus Erythematosus Systemic Lupus Erythaematosus SLE
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