All of Us, an ambitious health and genetics study aiming to enroll 1 million volunteers who represent the diversity of the United States, has reached a major milestone: the first release of nearly 100,000 whole genomes. AllofUsResearch
All of Us, an ambitious health and genetics study aiming to enroll 1 million volunteers who represent the diversity of the United States, has reached a major milestone: the first release of nearly 100,000 whole genomes. The DNA sequences are tied to anonymized health records from the participants, allowing the study of how gene variants influence health.
All of Us is modeled after similar studies in other countries, such as the UK Biobank, which holds genome and health data on 500,000 people of mostly European ancestry. The U.K. project has tied hundreds of DNA markers that vary among people to traits and illnesses, from. Started in 2018, the All of Us program run by the National Institutes of Health has enrolled about 330,000 participants so far.
All of Us is also releasing data from cruder DNA marker scans of an overlapping set of 165,000 participants that can reveal common genetic variants and their links to disease. But the whole genomes will allow researchers to look for rare variants that sharply raise a person’s disease risk and help reveal the underlying biology of the condition. Those rare variants are poorly understood in non-European populations, says geneticist Josh Denny, CEO of All of Us.
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