The production of estrogen in the thalamus appears to be curtailed by just one dose of nicotine, equivalent to that in a cigarette, reveals a whole brain analysis of healthy women. ECNP2022
in the thalamus appears to be curtailed by just one dose of nicotine, equivalent to that in a cigarette, reveals a whole brain analysis of healthy women in the first study of its kind.The researchers performed both MRI and scans in 10 healthy women using a tracer that binds to aromatase, also known as estrogen synthase.
“We were surprised to see that this effect could be seen even with a single dose of nicotine, equivalent to just one cigarette, showing how powerful the effects of smoking are on a womanEmphasizing the preliminary nature of the study and the need for a larger sample, she added: “We’re still not sure what the behavioral or cognitive outcomes are; only that nicotine acts on this area of the brain.
The researchers therefore turned to estrogen synthase, which regulates the synthesis of estrogen, and is highly expressed in the limbic system, a brain region associated withMoreover, estrogen synthase levels can be measured in vivo, and previous animal studies have indicated that nicotine inhibits estrogen synthase.
A whole brain analysis was then used to determine changes in non-displaceable binding potential of [11C]cetrozole to estrogen synthase between the two scans to indicate the availability of the enzyme at the two time points. Region-of-interest analysis using within-individual voxel-wise comparison confirmed reduced estrogen synthase levels in both the right and left thalamus , as well as in the subthalamic area.While men have lower levels of estrogen then women, “the reaction will take place anyway,” she said, although the “impact would be different.”
“Smoking has many adverse effects in men and in women, but this particular effect of nicotine on the reduction of estrogen production in women was not known before,” he added in the release.
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