Nicotine analogs allow e-cigarette makers to avoid traditional tobacco product regulations. But data on their safety in humans are lacking
A modified version of nicotine, the addictive ingredient in cigarettes, appeared in the U.S. vaping market in May 2023, prompting alarm among tobacco researchers. These products are being marketed as beyond the reach of the U.S. Food and Drug Administration. According to health researchers, this is the latest in a long history of moves by tobacco companies to avoid regulation and amounts to a large-scale human safety experiment.
“As I see it, this is just the latest chapter in the industry’s very long and nefarious history of evading or trying to evade laws that were enacted and intended to protect the health and well-being of not only adults but children in the United States,” says Lauren Kass Lempert, a public health researcher at the Center for Tobacco Control Research and Education at the University of California, San Francisco..
According to Sairam Jabba, a tobacco regulatory scientist at Duke University, 6-methylnicotine may not legally be nicotine, but it may share the worrying health profile that prompted tobacco regulations to begin with. As far back as the 1970s, tobacco companies researched nicotine analogs such as 6-methylnicotine to try to find for molecules that might be more desirable for users and avoid future regulations.
For Hanno Erythropel, a chemist at Yale University, who performed an analysis of Spree Bar products with Jabba, the unknowns surrounding nicotine analogs are worrying. Of the nine Spree Bar products tested, all had a discrepancy between, with the actual amount being much lower than stated. While this may seem reassuring, it could indicate intentional or accidental mislabeling because less of the potent ingredient is needed to produce the same effects as nicotine.
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