A breakdown of the betting lines for every NFL Week 4 matchup at DraftKings Sportsbook, including spreads, money lines, and over/under totals. The article provides the lines for all games, starting with the Thursday night game between the Seahawks and Cardinals.
NFL Week 4 kicks off Thursday night, as the Cardinals Bills host the Seahawks. Here are the lines for every Week 4 matchup at DraftKings Sports book as of Sept. 26. 2025 NFL Week 4 Odds THURSDAY, SEPT.
25 SEAHAWKS 23, CARDINALS 20 Spread: Seahawks -1.5 Total O/U: 43.5 This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. SUNDAY, SEPT. 28 VIKINGS @ STEELERS Spread: Vikings -2.5Moneyline: Vikings -142, Steelers +120Total O/U: 40.5 COMMANDERS @ FALCONS Spread: Falcons -2.5Moneyline: Commanders -135, Falcons +114Total O/U: 43.5 SAINTS @ BILLS Spread: Bills -15.5Moneyline: Bills -1350, Saints +800Total O/U: 47.5 BROWNS @ LIONS Spread: Lions -10Moneyline: Lions -535, Browns +400Total O/U: 44.5 PANTHERS @ PATRIOTS Spread: Patriots -5.5Moneyline: Patriots -238, Panthers +195Total O/U: 42.5 CHARGERS @ GIANTS Spread: Chargers -6Moneyline: Chargers -278, Giants +225Total O/U: 43.5 EAGLES @ BUCCANEERS Spread: Eagles -3.5Moneyline: Eagles -198, Bucs +164Total O/U: 44.5 TITANS @ TEXANS Spread: Texans -7Moneyline: Texans -410, Titans +320Total O/U: 39.5 COLTS @ RAMS Spread: Rams -3.5Moneyline: Rams -192, Colts +160Total O/U: 49.5 JAGUARS @ 49ERS Spread: 49ers -3Moneyline: 49ers -166, Jaguars +140Total O/U: 46.5 RAVENS @ CHIEFS Spread: Ravens -2.5Moneyline: Ravens -148, Chiefs +124Total O/U: 48.5 BEARS @ RAIDERS Spread: Raiders -1.5Moneyline: Bears -105, Raiders -112Total O/U: 47.5 PACKERS @ COWBOYS Spread: Packers -7Moneyline: Packers -360, Cowboys +285Total O/U: 47.5 MONDAY, SEPT. 29 JETS @ DOLPHINS Spread: Dolphins -2.5Moneyline: Dolphins -155, Jets +130Total O/U: 45.5 BENGALS @ BRONCOS Spread: Broncos -7.5Moneyline: Broncos -470, Bengals +360Total O/U: 44.5 Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, and follow leagues, teams and players to receive a personalized newsletter daily!
NFL Week 4 Odds Betting Matchups
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