University of Alberta researchers have identified an amino acid that may play a key role in predicting poor clinical outcomes and the treatment of long COVID.
In research published today in Cell Reports Medicine, the team says it has developed a predictive test to determine which patients with COVID-19 will go on to develop longer-term symptoms and proposes a clinical trial of an already-approved supplement as a potential treatment.
Gavin Oudit, principal investigator, professor of medicine in the U of A's Faculty of Medicine & Dentistry and director of the Heart Function Clinic at the Mazankowski Alberta Heart Institute Researchers analyzed the patients' blood for changes in proteins and metabolites, as well as signs of inflammation. They then reviewed results using machine learning and developed a predictive model composed of 20 molecules. They found their model predicted adverse clinical outcomes following discharge from acute infection with 83 per cent accuracy.
Related Stories"Patients with lower levels of taurine had a lot more symptoms, more of them were hospitalized and there was an increased risk for mortality," says Oudit. "Patients that had high levels of taurine and maintained high levels of taurine in their blood had much fewer ongoing symptoms and did better."
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