Drug classes commonly used to regulate blood pressure are not effective in preventing delirium acquired in the ICU. According to a recent study conducted by a team of researchers from the Regenstrief Institute and the universities of South Carolina and Indiana, the most widely used blood pressure m
Delirium is a serious and often temporary disturbance in mental functions that can occur as a result of a medical condition, such as an infection, an injury, or substance abuse. It is characterized by confusion, disorientation, and changes in perception, attention, and behavior. Delirium can be a sign of an underlying condition and requires prompt medical attention. It can also have significant consequences, including prolonged hospital stays and long-term cognitive impairment.
Each year, approximately seven million hospitalized patients in the U.S. are impacted by delirium, an acute failure of the brain. This condition is linked to prolonged hospital stays and ICU stays, increased use of mechanical ventilation, long-lasting cognitive problems, the need for placement in a nursing home, and a higher risk of death. The more severe and longer-lasting the delirium, the worse the post-discharge cognitive and functional outcomes are likely to be.
The observational study of the electronic health records of 4,791 racially diverse patients showed that taking these blood pressure medications for at least six months prior to admission to an ICU did not provide enough protective benefit or generate enough brain resilience to prevent delirium.
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