When a baby was born with three biological parents in 2016, there were concerns about the ethics and safety of the procedure.
with three biological parents in 2016, there were concerns about the ethics and safety of the procedure.into a donor egg with its own nuclear DNA removed. Doctors then fertilized the donor egg with the transplanted nuclear DNA using the husband's sperm.
This procedure was intended to prevent the child from inheriting a rare neurological disease called Leigh syndrome, which can be passed down through the maternal mitochondria.was that traces of maternal mitochondria extracted during the spindle transfer would multiply, creating health problems for the child.extracting the spindle-shaped group of chromosomes containing the mother's nuclear DNA from an egg.
However, a study looking at the effect of this procedure on the genetics of individual cells five days after fertilization has found that they are no different from a control group, suggesting that the procedure does not affect embryonic development in its early stages. The researchers used a single-cell triple omics sequencing method to examine the genome, DNA methylome, and transcriptome for"Our results suggest that spindle transfer seems generally safe for embryonic development, with a relatively minor delay in the DNA demethylation process at the blastocyst stage," the authors
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