Researchers explore the frequency of symptoms like chronic fatigue in IBD in relation to specific bacteria in the human gut.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Sep 11 2024 Research uncovers a potential link between gut bacteria and chronic fatigue in IBD patients, with specific microbes predicting the success of thiamine therapy for fatigue relief. Study: Thiamine-reduced fatigue in quiescent inflammatory bowel disease is linked to Faecalibacterium prausnitzii abundance. Image Credit: Kateryna Kon / Shutterstock.
Thiamine, which is more commonly referred to as vitamin B1, is an essential cofactor for multiple enzymatic pathways involved in energy production from the aerobic and anaerobic breakdown of carbohydrates. Thiamine is produced by most microorganisms and plants, but not by vertebrates; therefore, humans derive most of their thiamine from their diet, following which it is primarily absorbed in the small intestine.
Fecalibacterium is among the most abundant bacteria in the gut of a healthy human adult. The prevalence of Fecalibacterium in the human microbiome appears to be age-dependent, as it is found in up to 92% of adults and only 78% of the elderly. In one small preliminary study, high doses of thiamine reduced chronic fatigue, which may be mediated by alterations in the gut microbiota. The current study further assessed the role of the gut bacteria in mediating the effect of thiamine in patients with quiescent IBD and severe chronic fatigue.
Changes in microbiota Patients with IBD exhibited similar microbial diversity, with comparable abundances of butyrate and butyrate-producing bacteria, irrespective of the presence of fatigue. Moreover, thiamine therapy failed to change these parameters.
Fatigue Chronic Frequency Inflammatory Bowel Disease Tiredness
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