Researchers assessed whether dendritic spine head diameter in the temporal cortex is a better predictor of episodic memory performance in older adults than synapse quantity, accounting for β amyloid plaques, neurofibrillary tangles, and sex.
By Vijay Kumar MalesuReviewed by Danielle Ellis, B.Sc.Aug 12 2024 In a recent study published in Science Advances, a group of researchers assessed whether dendritic spine head diameter in the temporal cortex is a better predictor of episodic memory performance in older adults than synapse quantity, accounting for β amyloid plaques , neurofibrillary tangles , and sex.
About the study Postmortem samples of brain areas Brodmann area 6 and BA37 were obtained from participants in the Religious Orders Study and Rush Memory and Aging Project , which includes individuals who enroll without known dementia and agree to annual clinical evaluations and brain donation upon death.
Dendritic spines and synaptic markers were visualized using Golgi-Cox staining of brain samples from BA6 and BA37. Imaging of dendrites was performed by a blinded experimenter using bright-field microscopy at high magnification. Dendritic segments meeting specific criteria were selected for analysis, and 3D digital reconstructions of dendrites and spines were conducted using specialized software.
Related StoriesThe datasets from BA37 and BA6 were subjected to a supervised learning algorithm to identify specific dendritic spine features that might predict episodic memory performance beyond the effects of other variables, such as AD-related neuropathology. The samples were divided into a discovery set and a validation set , with three cases excluded due to missing data.
Brain Brain Cell Cell Dementia Alzheimer's Disease Cortex Magnification Microscopy Morphology Neurodegenerative Diseases Pathology Protein Research Spine Synapse
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