Editing technology is precise and broadly applicable to all tissues and species. Scientists at Duke University have developed an RNA-based editing tool that targets individual cells, rather than genes. It is capable of precisely targeting any type of cell and selectively adding any protein of int
Tagging and illuminating only the inhibitory “brake” cells in human brain tissue is just one of many things the new tool from Duke University, CellREADR, can do. Credit: Derek Southwell, Duke UniversityScientists at Duke University have developed an-based editing tool that targets individual cells, rather than genes. It is capable of precisely targeting any type of cell and selectively adding any protein of interest.
“We’re excited because this provides a simplified, scalable and generalizable technology to monitor and manipulate all cell types in any animal,” Huang said. “We could actually modify specific types of cell function to manage diseases, regardless of their initial genetic predisposition,” he said. “That’s not possible with current therapies or medicine.”
are made-up of complementary molecules that are inherently attracted to each other, RNA has the same magnetic potential to link with another piece of RNA if it has matching molecules. Knowing this, Qian designed CellREADR’s stop sign using the same specific nucleotide ADAR edits in double-stranded RNA. The stop sign, which prevents the protein blueprints from being built, is only removed once CellREADR’s sensor docks to its target RNA sequence, making it highly specific for a given cell type.
The team’s careful planning and design paid off as they were then able to demonstrate CellREADR accurately labelled specific brain cell populations in living mice, as well as effectively added activity monitors and control switches where directed. It also worked well in rats, and in human brain tissue collected from epilepsy surgeries.
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