New findings shed light on the link between the TP53 protein-coding gene and neurodevelopmental and psychiatric conditions such as autism spectrum disorder. Researchers have established that the protein p53 plays a crucial role in managing sociability, repetitive behavior, and learning and memory
A recent study uncovers a direct link between the protein p53 and autism-like behavior in mice, revealing its crucial role in managing sociability, repetitive actions, and learning and memory related to the hippocampus.
“This study shows for the first time that p53 is linked directly to autism-like behavior,” said Nien-Pei Tsai, an associate professor of molecular and integrative biology at the University of Illinois Urbana-Champaign and a researcher at the Beckman Institute for Advanced Science and Technology. In living systems, genes act as a biological version of binary code, using the letters A, C, G, and T instead of ones and zeroes to spell out cellular marching orders. Some genes — called coding genes — instruct cells to create proteins with specific functions. For example, the gene TP53 instructs cells to create the protein p53; its job is to regulate how other genes are expressed.
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