New Research Suggests That Common HIV Drugs May Reduce Alzheimer’s Risk

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New Research Suggests That Common HIV Drugs May Reduce Alzheimer’s Risk
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Recent research indicates that HIV drugs may reduce the incidence of Alzheimer’s disease. The study, analyzing data from over 225,000 patients, shows promising results for using reverse transcriptase inhibitors in older, HIV-positive individuals to potentially lower Alzheimer’s occurrence.

Jerold Chun, M.D. Ph.D., is a professor in the Center for Genetic Disorders and Aging Research at Sanford Burnham Prebys. Credit: Sanford Burnham PrebysHIV and many other viruses rely on RT to hijack a host’s cells to establish a chronic infection, so drugs that block the RT enzyme’s activity have become a common part of treatment cocktails for keeping HIV at bay.

“Thus, we looked at HIV-positive individuals taking RT inhibitors and other combined antiretroviral therapies as they aged, and asked the question: How many of them got Alzheimer’s disease?” says Chun. “And the answer is that there were many fewer than might have been expected compared to the general population.”Of the more than 225,000 individuals with claims data in the study, just shy of 80,000 were HIV-positive individuals over the age of 60.

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