A groundbreaking study has uncovered a link between a mitochondrial metabolite and the triggering of an inflammatory response. As essential components of our cells, mitochondria play a crucial role in performing various tasks such as chemical reactions that are necessary for cell functioning. One of
, has now developed a new mouse and cell model together with the research group led by Professor Prudent of the University of Cambridge to deepen the understanding of aggressive kidney cancer.
In the models, the silencing of the fumarate hydratase gene can be temporally controlled by the scientists. Using a combination of high-resolution imaging techniques and precise biochemical experiments, the scientists have shown that fumarate causes mitochondrial damage. This in turn releases the genetic material of the mitochondria in small vesicles called mitochondrial-derived vesicles. trigger an immune reaction that eventually leads to inflammation.
Reference: “Fumarate induces vesicular release of mtDNA to drive innate immunity” by Vincent Zecchini, Vincent Paupe, Irene Herranz-Montoya, Joëlle Janssen, Inge M. N. Wortel, Jordan L. Morris, Ashley Ferguson, Suvagata Roy Chowdury, Marc Segarra-Mondejar, Ana S. H. Costa, Gonçalo C.
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