An MD Anderson study provides a deeper understanding of the progression of gastric cancer and highlights a potential therapeutic target. A recent study conducted by scientists at The University of Texas MD Anderson Cancer Center offers new insight into how the tumor microenvironment changes during
Researchers at MD Anderson Cancer Center have uncovered key dynamics in gastric adenocarcinoma’s tumor microenvironment, identifying SDC2 as a promising new treatment target.
Gastric adenocarcinoma ranks among the deadliest cancers worldwide, primarily due to its natural resistance to treatment. However, the cellular and molecular processes that drive the transition from early pre-cancerous stages to tumor formation and metastasis remain largely unclear. This study illuminates the ways in which different immune and stromal cell subsets change throughout the progression of gastric cancer.The study was conducted by Linghua Wang, M.D., Ph.D.
By obtaining single-cell RNA sequencing data from 68 gastric adenocarcinoma samples encompassing various disease stages — including precancerous lesions, localized tumors, and distant metastases — along with normal tissue and peripheral blood samples, the team characterized the diverse immune and stromal cell populations within the tumor microenvironment and discovered exploitable targets to modulate the tumor microenvironment.
A notable discovery is that two ecotypes correlated with different histological, genomic, and clinical features of primary gastric adenocarcinomas. Tumors categorized as EC3 were composed mainly of immune cell subsets, whereas EC6 tumors predominantly included stromal cell subsets. Patients with EC6 tumors had more aggressive disease and significantly shorter survival compared to those with EC3 tumors.
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