New research could lead to a simple bloodtest for braintumors RSocPublishing
The Bristol-led research, published in the, involved the development of mathematical models to assess the current use ofThis research is part of a wider University of Bristol-led CRUK project to develop an affordable point-of-care blood test to diagnose brain tumors. This cross-disciplinary project combines biomarker discovery, development of fluorescent nanoparticle and new testing techniques with computational modeling.
In this recent study, mathematical models were developed and paired with experimental data. The researchers found that for the prospective GBM biomarker Glial fibrillary acidic protein lowering the current biomarker threshold could lead to earlier detection of GBMs. The team also used computational modeling to explore the impact of tumor characteristics and patient differences on detection and strategies for improvements.
Dr. Johanna Blee, lead author and Research Associate in the University of Bristol's Department of Engineering Mathematics, said,"Our findings provide the basis for further clinical data on the impact of lowering the current detection threshold for the known biomarker, GFAP, to allow earlier detection of GBMs using blood tests.
"These mathematical models could be used to examine and compare new biomarkers and tests for brain tumors as they emerge. We are hopeful this research will ultimately aid the development of a simple blood test for
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