A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine researchers.
Weill Cornell Medicine Jul 23 2024 A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine researchers.
Dr. Ching-Hwa Sung, the Betty Neuwirth Lee and Chilly Professor in Stem Cell Research and professor of cell biology in ophthalmology and of cell and developmental biology at Weill Cornell Medicine For the study, the researchers engineered mice that lack the gene for a protein called VPS35 just in rod cells, the main light-sensing neurons of the retina. VPS35 is known for helping cells to distribute molecules to their corresponding destinations, including sending abnormal proteins for degradation. A mutation in VPS35's gene has been linked to a familial form of Parkinson's disease.
Related Stories"We think this explains why we saw such a strong effect of knocking out this protein," Dr. Sung said.
Cell Cell Biology Developmental Biology Gene Medicine Neurons Ophthalmology Parkinson's Disease Pathology Protein Research
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