A novel therapeutic approach for neonatal hypoxic-ischemic (HI) brain injury.
By Tarun Sai LomteJun 11 2024Reviewed by Lily Ramsey, LLM In a recent study published in Biomedicine and Pharmacotherapy, researchers described a novel therapeutic approach for neonatal hypoxic-ischemic brain injury.
Studies have provided evidence for dietary supplements and oral omega-3 fatty acids as potential neuro- and cardioprotective strategies. The emulsions were incubated with a buffer with or without bovine lipoprotein lipase . Human plasma containing apolipoprotein C-II was added to the mixture. Released free FA was measured.
One group of rats received TH for five hours post-HI insult. Negative geotaxis and righting reflex performances were evaluated 24 hours after the injury. Twenty-four hours after reperfusion, mouse brains were obtained , and infarct sizes were computed. The zeta potential was -50 mV for DGs and -35 mV for TGs. Basal FFA levels were similar between DG and TG emulsions. The highest lipolysis was observed in n-3 DG emulsion, with over 1.5-fold more FFAs released than n-3 TG emulsions.
Newborn Biomedicine Blood Cerebral Palsy Docosahexaenoic Acid Encephalopathy Fatty Acids Hypothermia Labor Oxygen Rat Model Supplements Triglyceride
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