The new technique will help differentiate between cancer tumors and healthy cells by providing a visual map of tumors using fluorescent dyes.
in the body. These chemicals then light up during a process called ‘fluorescence’, thus helping the doctors identify the parts of tumors that weren’t removed during surgery.
To improve the visual quality of the images, the researchers then used an HD camera to capture short-wave infrared light fluorescence, which is invisible to the naked eye.Neuroblastoma is a type of cancer that mostly occurs in infants and children. It develops from immature nerve cells found in various parts of the body.
The study recognizes that the treatment and results of high-risk Neuroblastoma patients remain poor because surgeries can be tricky. While a radical resection, meaning the removal of the entire tumor along with some healthy tissues around it, is known to be the gold standard among oncologists, it’s a challenging surgery because Neuroblastoma infiltrates the abdominal and thoracic cavities, major nerves and vessels, and is tightly connected to the surrounding organs.
The study notes that although many of these tumor-specific techniques have been developed and are under investigation in clinical trials in adult populations, none are yet available for use in pediatric oncology. This technique was developed by engineers at the Wellcome/EPSRC Centre for Interventional and Surgical Sciences at UCL and surgeons at Great Ormond Street Hospital .Fluorescence-guided surgery is set to play a pivotal role in the intraoperative management of pediatric tumors. Short-wave infrared imaging has advantages over conventional near-infrared I imaging with reduced tissue scattering and autofluorescence.
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