Strokes lead to irreversible damage to the brain and are one of the most common causes of dependency or death. As the cellular reactions to a cerebral infarction are not yet fully understood, there is a lack of possible approaches to promote the regeneration of damaged nerve tissue in the brain.
A new study closes crucial gaps in our knowledge and paves the way for research into new, targeted therapeutic strategies.
In order to investigate the activity of individual cells in the brain after a stroke, the research team led by first author Daniel Bormann and study leaders Hendrik J. Ankersmit and Michael Mildner used single-cell RNA sequencing in animal models, which are already established in stroke research. Using this method, the researchers were able to identify different cell types and their reactions in the early phase after a cerebral infarction.
In addition, it was discovered that certain immune cells , which are also found in the vicinity of the infarct, release a signalling molecule . This molecule could play a decisive role in directing the glial cells to the edge of the infarct, where they are needed, among other functions, to form a barrier between the damaged and healthy tissue.
"The insights gained in our international and interdisciplinary study are a promising resource for developing novel targeted therapeutic strategies," says Daniel Bormann with a view to further scientific investigations.Daniel Bormann, Michael Knoflach, Emilia Poreba, Christian J.
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