Researchers have developed a groundbreaking microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains. The new method, called TRISCO, has the potential to transform our understanding of brain function, both in normal conditions and in disease, according to the new study.
Researchers have developed a groundbreaking microscopy method that enables detailed three-dimensional RNA analysis at cellular resolution in whole intact mouse brains. The new method, called TRISCO, has the potential to transform our understanding of brain function, both in normal conditions and in disease, according to the new study.
In the study, up to three different RNA molecules were analysed simultaneously. The next step for the researchers is to expand the number of RNA molecules that can be studied to around a hundred, using a technique called multiplex RNA analysis. This could provide even more detailed information about brain function and disease states.
Not only is TRISCO suitable for studying intact mouse brains, but the study demonstrates it can be used for larger brains, such as those of guinea pigs, and various tissues like kidney, heart, and lung. The study is a collaboration between Karolinska Institutet and Karolinska University Hospital.
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