Science, Space and Technology News 2024
A new study reveals that gut bacteria may be responsible for sight loss in certain inherited eye diseases, suggesting the potential for antimicrobial treatment. This discovery offers hope for alternative treatments to prevent blindness in affected individuals.
The international study observed that in eyes with sight loss caused by a particular genetic mutation, known to cause eye diseases that lead to blindness, gut bacteria were found within the damaged areas of the eye.and jointly led by researchers in China, say their findings suggest that the genetic mutation may relax the body’s defenses, thus allowing harmful bacteria to reach the eye and cause blindness.
The CRB1 gene is associated with inherited eye disease, most commonly forms of Leber congenital amaurosis and retinitis pigmentosa ; the gene is the cause of 10% of LCA cases and 7% of RP cases worldwide.Using mouse models, the research team discovered the CRB1 gene is key to controlling the integrity of the lower gastrointestinal tract, the first ever such observation.
Inherited eye diseases are the UK’s leading cause of blindness in working-age people. Onset of disease may vary from very early childhood to adulthood, but deterioration is irreversible and has lifelong implications. To date, the development of treatments has largely focused on gene therapies.
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