Pharmacogenetics can help patients avoid drugs that won't work or cause side effects. More doctors are using it. Should you?
What if there were tests that could tell you whether the following drugs were a good match for your patients: Antidepressants, statins, painkillers, anticlotting medicines, chemotherapy agents, HIV treatments, organ transplant antirejection drugs, proton pump inhibitors for heartburn, and more?
Through a cheek swab or blood sample, the MyRx program — and a growing number of health system programs, doctors' offices, and home tests available across the United States — gives consumers a window on inherited gene variants that can affect how their body activates, metabolizes, and clears away medications from a long list of widely used drugs.These tests work by looking for genes that control drug metabolism.
PGx checks are already strongly recommended or considered routine before some medications are prescribed. These include abacavir , an antiviral treatment for HIV that can have severe side effects in people with one gene variant. "One of the key benefits of pharmacogenomic testing is in preventing adverse drug reactions," Wiisanen said."Testing of the thiopurine methyltransferase enzyme to guide dosing with 6-mercaptopurine or azathioprine can help prevent myelosuppression, a serious adverse drug reaction caused by lower production of blood cells in bone marrow.
For help figuring out if a test looks for the right gene variants, Caudle and Wright recommended checking with the's website. The group published a brief list of best practices for phamacogenomic testing in 2019. And it keeps aof gene variants that should be included in tests. Clinical guidelines from the CPIC and other groups, available onThe price tag for a test is typically several hundred dollars — but it can run as high as $1000-$2500.
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