New risk thresholds used to guide statin therapy for primary prevention of atherosclerotic CVD in the latest European guidelines dramatically reduce eligibility for statin use in low-risk countries, a new study has found.
describes the results of the study as “alarming,” and, if confirmed, says the guidelines should be revisited to “prevent a step backwards in the use of statins in primary prevention.”
This is in sharp contrast to the previous 2019 European guidelines as well as current UK-NICE and US-ACC/AHA guidelines that provide class I/strong recommendations to 20%, 26%, and 34% of individuals, respectively, with better clinical performance in both men and women, the authors report. “If we use the UK or US guidelines far more people in these low-risk European countries would be eligible for statin therapy and we would prevent far more events than if we use the new ESC guidelines,” he added.
Asked whether there is an argument that most individuals in low-risk countries may not need to take a statin, Mortensen countered: “One of the reasons the risk is low in many of these European countries is the high use of preventative medication. So, if a threshold that is too high is used most people will not take a statin anymore and the risk in these countries will increase again.”
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