New engineered peptides could prevent the superbug crisis AntibioticResistance Staph Peptide PLG0206 PLOSONE PittTweet
By Dr. Priyom Bose, Ph.D.Sep 22 2022Reviewed by Benedette Cuffari, M.Sc. Infection with multidrug-resistant organisms, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecium, Escherichia coli , Staphylococcus aureus, Enterobacter spp., and Acinetobacter baumannii, is a significant public health threat to the global population. However, at present, no drugs are available that can effectively resist MDR organisms.
Naturally occurring antimicrobial peptides have exhibited intrinsic defense mechanisms against numerous species. The scarcity in the clinical development of AMPs has been attributed to their toxicity, limited in vivo activity, lack of systemic activity, and suboptimal pharmacokinetic properties. Most traditional antibiotics lose their efficacy against bacterial biofilms compared to planktonic cells. Considering this limitation, the present study utilized a sizeable clinical isolate library of ESKAPEE pathogens to determine if PLG0206 possessed rapid, broad-spectrum, bactericidal activity against both Gram positive and Gram negative MDR pathogens in both biofilm and planktonic growth states.
Animal model-based experiments also indicated a low toxic profile for systemic and local use of PLG0206. A large rabbit PJI animal model study confirmed the ability of PLG0206 to maintain biofilm-associated activity with no apparent toxicity. Notably, all animals exhibited prolonged survival after a single treatment with PLG0206 after S. aureus infection.
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