The phase two trial is the first study to demonstrate a swift and substantial decrease in brain pressure and the frequency of monthly headaches. A new trial has discovered that individuals suffering from 'blinding' headaches, known as Idiopathic Intracranial Hypertension (IIH), could potentially be
Idiopathic Intracranial Hypertension headaches are a condition characterized by increased pressure within the skull without an identifiable cause. Often mistaken for migraines, these headaches can cause debilitating pain and are commonly associated with symptoms such as blurred vision, tinnitus, and even temporary vision loss.
The trial also saw significant reductions in the number of headaches across the 12 weeks that participants took part, with an average of 7.7 fewer days per month of headaches compared to the baseline, compared to only 1.5 fewer days in the placebo arm.University of Birmingham “We are delighted to see that the phase two trial resulted in our treatment group having lower brain pressure both immediately and after 12 weeks and nearly 8 fewer headache days across the 12-week period, and that all the women were able to continue the treatment throughout with few adverse effects. We now hope to see a much larger trial of exenatide to literally ease the pressure for the many people around the world suffering with IIH.
Dr James Mitchell, Lecturer in Neurology at the University of Birmingham and first author of the paper said: “The results of this clinical trial are a shot in the arm for finding clinical treatments for IIH.
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