Science, Space and Technology News 2024
The study reveals that the RNA modification N4-acetylcytidine plays a crucial role in the formation of stress granules and the cellular response to stress, offering new insights into the molecular mechanisms involved and identifying potential targets for disease treatment.
They also show that ac4C on mRNA can mediate the localization of proteins to stress granules. Their results suggest that acetylation of mRNA regulates the localization of both stress-sensitive transcripts and RNA-binding proteins to stress granules and adds to our understanding of the molecular mechanisms responsible for stress granule formation.Stress granules are membrane-less assemblies of mRNA-protein complexes that arise from mRNAs stuck in translation initiation.
Stress granules have been extensively studied, and it is well-established that they form when translation initiation is limited a variety of roles for stress granules within the cell have been proposed. While stress granule assembly and disassembly can be regulated by various post-translational modifications the impact of RNA modifications on their formation, dispersal, and function remains largely unclear.
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