A novel test utilizing synovial fluid biomarkers shows promise in differentiating osteoarthritis (OA) from inflammatory arthritis. The test, based on the ratio of cartilage oligomeric matrix protein (COMP) and interleukin 8 (IL-8), could aid in diagnosis, particularly in cases with ambiguous symptoms.
A new diagnostic test can accurately distinguish osteoarthritis (OA) from inflammatory arthritis using two synovial fluid biomarkers, according to research published. The test uses an algorithm that incorporates concentrations of cartilage oligomeric matrix protein (COMP) and interleukin 8 (IL-8) in synovial fluid . The researchers hypothesized that a ratio of the two biomarkers could distinguish between primary OA and other inflammatory arthritic diagnoses.
They wrote, “Primary OA is unlikely when either COMP concentration or COMP/IL‐8 ratio in the synovial fluid is low since these conditions indicate either lack of cartilage degradation or presence of high inflammation.” “In contrast, a high COMP concentration result in combination with high COMP/IL‐8 ratio would be suggestive of low inflammation in the setting of cartilage deterioration, which is indicative of primary OA.” In patients with OA, synovial fluid can be difficult to aspirate in sufficient amounts for testing, said Amanda E. Nelson, MD, MSCR, professor of medicine in the Division of Rheumatology, Allergy, and Immunology at the University of North Carolina at Chapel Hill. She was not involved with the research. “If synovial fluid is present and able to be aspirated, it is unclear if this test has any benefit over a simple, standard cell count and crystal assessment, which can also distinguish between osteoarthritis and more inflammatory arthritides,” she said.
Osteoarthritis Inflammatory Arthritis Diagnostic Test Biomarkers Synovial Fluid
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