New DCFHP-alum COVID-19 vaccine candidate shows durable, broad-spectrum protection in non-human primates COVID19vaccine DCFHP protein_nanoparticle OmicronBQ1 SARSCoV2 vaccinebooster COVID NatureComms Stanford czbiohub StanfordMed
By Dr. Priyom Bose, Ph.D.Apr 18 2023Reviewed by Benedette Cuffari, M.Sc. The ongoing coronavirus disease 2019 pandemic, which is caused by the severe acute respiratory syndrome coronavirus 2 , has claimed more than 6.89 million lives worldwide.
The limitations of current COVID-19 vaccines In May 2022, the World Health Organization estimated that about one billion individuals globally have remained unvaccinated against COVID-19. The affordability issue of the COVID-19 vaccine has significantly limited mass vaccination, as most available vaccines require low-temperature storage and transportation that increase the cost of vaccine programs.
Ferritin-based nanoparticle vaccines are associated with strong humoral immune responses against SARS-CoV-2, as well as significant efficacy and safety profiles. One protein nanoparticle-based vaccine, S∆C-Fer, contains an inactivated polybasic cleavage site that has been shown to improve neutralizing titers.
About the study A recent Nature Communications study introduced the updated version of S∆C-Fer, which has been called Delta-C70-Ferritin-HexaPro . The previously present 2P stabilizing substitutions were supplemented with four proline substitutions to develop a six-proline substituted form of the vaccine.
Study findings DCFHP-alum was found to induce a robust and durable immune response in mice against SARS-CoV-2 VOCs. Importantly, this vaccine candidate also remained stable in wide-ranging temperatures from 4°C to 37°C for at least 14 days.
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