Combining precise genome engineering and protein activity profiling to methodically study thousands of cancer genes, scientists were able to pinpoint promising cancer drug targets.
Searching for new ways to block the growth of cancer cells is like looking for a needle in a haystack. Tumor cells rely on thousands of proteins to function, but only a few of those proteins can be precisely targeted by drugs to treat cancer safely and effectively. Now, a team at Scripps Research and the Broad Institute of Harvard and MIT has spearheaded a new method to hone in on new drug targets most likely to impact multiple cancers.
"We needed a way to narrow down the list to cysteines that have an important functional impact on cancer-relevant proteins," says Haoxin Li, a postdoctoral research associate at Scripps Research and first author of the new paper. "We have found compounds targeting TOE1 and showed they can block its normal activity through a fascinating mechanism that is likely to impact cancer cell growth," says Li.
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